https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9196 Wed 11 Apr 2018 10:54:31 AEST ]]> The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1955 Sat 24 Mar 2018 08:33:18 AEDT ]]> The association between CD36 and Lyn protein tyrosine kinase is mediated by lipid https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1051 Sat 24 Mar 2018 08:32:13 AEDT ]]> A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1093 Sat 24 Mar 2018 08:31:57 AEDT ]]> Antibody binding to individual short consensus repeats of decay-accelerating factor enhances enterovirus cell attachment and infectivity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2788 Sat 24 Mar 2018 08:27:07 AEDT ]]> Active Lyn protein tyrosine kinase is selectively enriched within mermbrane microdomains of resting platelets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2790 Sat 24 Mar 2018 08:27:05 AEDT ]]> Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10609 Sat 24 Mar 2018 08:13:49 AEDT ]]> Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18969 Sat 24 Mar 2018 07:58:53 AEDT ]]> FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19310 Sat 24 Mar 2018 07:52:15 AEDT ]]> T-cell acute lymphoblastic leukemia express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38689 FAT1 gene was cloned over 20 years ago, but there has only been an incremental understanding of its functional role in cancer and developmental disorders. FAT1 is highly expressed in a large proportion of cases of T-cell acute lymphoblastic leukemia (T-ALL) and B-cell ALL compared to their normal counterparts suggesting an oncogenic function. Conversely, the FAT1 gene is also recurrently mutated in a small subset of TALL cases and also in chronic lymphocytic leukemia. Functionally, the FAT1 cadherin has been implicated in Wnt signaling, hippo signaling and more recently mitochondrial function which together suggests a role outside the classical cadherin function in regulating cell-cell adhesion. Here we show that T-ALL cell lines and clinical samples express a unique N-terminal truncated FAT1 mRNA transcript that generates a protein from a novel transcriptional start site within a retained intronic sequence. This novel transcript is regulated independently of full-length FAT1 and results in the expression of a truncated protein lacking almost the entire extracellular domain of FAT1. Significantly, this truncated protein is a novel biomarker for T-ALL and was found to cooperate with NOTCH in driving T-ALL in vivo, suggesting that in the context of T-ALL, this truncated protein may act as an oncogene.]]> Fri 12 Aug 2022 13:35:10 AEST ]]>